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KMID : 1123820080100010057
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Health & sports medicine
2008 Volume.10 No. 1 p.57 ~ p.70
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Mechanism of endothelial cell inflammation in adipose tissue
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Lee Hyuek-Jong
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Abstract
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The purpose of this review is to understand the mechanism of endothelial cell(EC) activation induced by inflammation which is occurred in adipose tissue of obese patients. Low-grade of systemic inflammation is intensively linked with excessive development of adipose tissue and leads to onset of several disease like insulin resistance, Type2 diabetes or atherosclerosis. Also it is associated with recruitment of more macrophage into the fat tissue. Macrophage in adipose tissue is regarded as a major source for inflammatory cytokines which activates many cells including adipocytes and EC etc. Once ECs are activated by TNF-α, IL-6 or IL-1, adhesion molecules(ICAM-1. VCAM-1, MCP-1 etc) expressed on endothelial cell recruit leukocytes by binding their ligands of leukocyte. Infiltrated monocytes are differentiated to macrophage in the tissue and express many inflammatory cytokines again. After all, the activation of EC in adipose tissue is related with various stimuli which is occurred through the cross-talk between all the cells in adipose tissue.
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KEYWORD
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inflammation, adipose tissue, endothelial, cell, macrophage
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